/*
common.css
*/
@charset "UTF-8";

/* reset */
html,body,div,span,object,iframe,h1,h2,h3,h4,h5,h6,p,blockquote,pre,abbr,address,cite,code,del,dfn,em,img,ins,kbd,q,samp,small,strong,sub,sup,var,b,i,dl,dt,dd,ol,ul,li,fieldset,form,label,legend,table,caption,tbody,tfoot,thead,tr,th,td,article,aside,figure,footer,header,hgroup,menu,nav,section,time,mark,audio,video{margin:0;padding:0;border:0;outline:0;font-size:100%;vertical-align:baseline;background:transparent;}article,aside,figure,footer,header,hgroup,nav,section{display:block;}img,object,embed{vertical-align: bottom;}html{overflow-y:scroll;}ul{list-style:none;}blockquote,q{quotes:none;}blockquote:before,blockquote:after,q:before,q:after{content:'';content:none;}a{margin:0;padding:0;font-size:100%;vertical-align:baseline;background:transparent;}del{text-decoration:line-through;}abbr[title],dfn[title]{border-bottom:1px dotted #000;cursor:help;}table{border-collapse:collapse;border-spacing:0;}th{font-weight:bold;vertical-align:bottom;}td{font-weight:inherit;vertical-align:top;}hr{display:block;height:1px;border:0;border-top:1px solid #ccc;margin:1em 0;padding:0;}input,select{vertical-align:middle;}pre{white-space:pre;white-space:pre-wrap;white-space:pre-line;word-wrap:break-word;}input[type="radio"]{vertical-align:text-bottom;}input[type="checkbox"]{vertical-align:bottom;*vertical-align:baseline;}select,input,textarea{font:99% sans-serif;}table{font-size:inherit;font:100%;}a:hover,a:active{outline:none;}strong,th{font-weight:bold;}td,td img{vertical-align:top;}sub,sup{font-size:75%;line-height:0;position:relative;}sup{top:-0.5em;}sub{bottom:-0.25em;}pre,code,kbd,samp{font-family:monospace,sans-serif;}label,input[type=button],input[type=submit],button{cursor:pointer;}button,input,select,textarea{margin:0;}button{width:auto;overflow:visible;}[hidden]{display:none !important;}[disabled]{cursor:not-allowed;}:focus:not(:focus-visible){outline:none;}

/* clear */
.clear:before,.clear:after{content:"\0020";display:block;height:0;overflow:hidden;}.clear:after{clear:both;}.clear{zoom:1;}

/* --------------------------------------------------
   Base
-------------------------------------------------- */

:root {
    --color-primary: #122c46;
    --color-green: #007f89;
    --color-blue: #4f81bd;
    --color-heading: #122c46;
    --color-text: #343b46;
    --color-background: #ffffff;
    --color-lightgray: #f7f8fa;
	
    --font-body: "Aptos", "Segoe UI", Arial, sans-serif;
    --font-heading: "Aptos Display", "Aptos", Arial, sans-serif;	
}

*,
*::before,
*::after {
    box-sizing: border-box;
}

html {
    font-size: 62.5%;
	scroll-behavior: smooth;
}

@media (prefers-reduced-motion: reduce) {
    html {
        scroll-behavior: auto;
    }
}

body {
    margin: 0;
    font-family: var(--font-body);
	font-weight: 400;
    line-height: 1.7;
    color: var(--color-text);
}



h1, h2, h3, h4, h5, h6 {
    font-family: var(--font-heading);
    font-weight: 700;
    color: var(--color-heading);
}

img {
    max-width: 100%;
    height: auto;
}

a {
    color: inherit;
    text-decoration: none;
}

section {
	margin-top: 96px;
}
@media (max-width: 768px) {
	section {
		margin-top: 48px;
	}
}


p {
    margin-top: 24px;
    color: var(--color-text);
    font-family: var(--font-body);
    font-size: 17px;
    line-height: 1.8;
}


h2 {
    margin: 0;
    color: var(--color-green);
    font-family: var(--font-heading);
    /*font-size: clamp(28px, 3vw, 36px);*/
	font-size: clamp(24px, 2.5vw, 32px);
    font-weight: 700;
	line-height: 1.4;
}

h3 {
    margin: 0;
    color: var(--color-blue);
    font-family: var(--font-heading);
    font-size: 22px;
    font-weight: 400;
}

/* ========================================
   Japanese Typography
======================================== */

html[lang^="ja"] {
    --font-body: "Yu Mincho", "YuMincho", "游明朝", serif;
    --font-heading: "Yu Gothic", "YuGothic", "游ゴシック", sans-serif;
}



/* 日本語本文：游明朝 */
html[lang^="ja"] body {
    font-family: "Yu Mincho", "YuMincho", "游明朝", "Hiragino Mincho ProN", serif;
}

/* 日本語見出し：游ゴシック Bold */
html[lang^="ja"] h1,
html[lang^="ja"] h2,
html[lang^="ja"] h3,
html[lang^="ja"] h4,
html[lang^="ja"] h5,
html[lang^="ja"] h6 {
    font-family: "Yu Gothic", "YuGothic", "游ゴシック", "Hiragino Kaku Gothic ProN", sans-serif;
    font-weight: 700;
}

html[lang^="ja"] .site-header,
html[lang^="ja"] .hero-subtitle,
html[lang^="ja"] .page-subtitle,
html[lang^="ja"] .highlight-content p,
html[lang^="ja"] .challenge-description,
html[lang^="ja"] .platform-text p,
html[lang^="ja"] .germ-card-content p,
html[lang^="ja"] .note,
html[lang^="ja"] .bioprocess-step,
html[lang^="ja"] .bioprocess-total span,
html[lang^="ja"] .application-item,
html[lang^="ja"] .application-item p,
html[lang^="ja"] .leadership-card,
html[lang^="ja"] .leadership-card p,
html[lang^="ja"] .network-card,
html[lang^="ja"] .network-card p,
html[lang^="ja"] .roadmap-item,
html[lang^="ja"] .roadmap-item p,
html[lang^="ja"] .contact-details,
html[lang^="ja"] .footer-nav,
html[lang^="ja"] th, 
html[lang^="ja"] td {
    font-family: "Yu Gothic", "YuGothic", "游ゴシック", "Hiragino Kaku Gothic ProN", sans-serif;
}


/* Utilities
---------------------------------------- */

.u-text-white {
	color: var(--color-white);
}

.u-text-center {
	text-align: center !important;
}

.u-text-left {
	text-align: left;
}

.mt-0 {
    margin-top: 0 !important;
}

.mt-8 {
    margin-top: 8px;
}

.mt-16 {
    margin-top: 16px;
}

.mt-24 {
    margin-top: 24px;
}

.mt-40 {
    margin-top: 40px;
}

/* Header */

.site-header {
    background: #fff;
    border-bottom: 1px solid #e5e5e5;
}

.header-inner {
    max-width: 1280px;
    margin: 0 auto;
    padding: 0 30px;
    min-height: 90px;

    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 30px;
}

.site-logo {
    font-size: 28px;
    font-weight: 700;
    color: #343b46;
}

.site-logo img {
    display: block;
    width: 150px;
    height: auto;
}

.site-logo a {
    text-decoration: none;
    color: inherit;
}

/* Navigation */

.nav-menu {
    display: flex;
    align-items: center;
    gap: 24px;
    list-style: none;
    margin: 0;
    padding: 0;
}

.nav-menu a {
    text-decoration: none;
    color: #343b46;
    font-size: 13px;
    font-weight: 600;
    white-space: nowrap;
}

.nav-menu a:hover {
    opacity: 0.65;
}
	
/* Language Switcher */

.language-switcher {
    display: flex;
    align-items: center;
    gap: 8px;
    font-size: 13px;
    font-weight: 600;
    white-space: nowrap;
}

.language-switcher a {
    color: #999;
    text-decoration: none;
    transition: color 0.2s;
}

.language-switcher a:hover {
    color: #343b46;
}

.language-switcher a.active {
    color: #343b46;
}

.lang-separator {
    color: #ccc;
}


/* ========================================
   Hamburger Menu
======================================== */

/* PCでは非表示 */
.menu-toggle {
    display: none;
}

/* ========================================
   Tablet / Mobile
======================================== */

@media (max-width: 900px) {

    .header-inner {
        position: relative;
        min-height: 75px;
        padding: 0 20px;
        gap: 20px;
    }

    .site-logo {
        order: 1;
        flex-shrink: 0;
    }	
	
    .site-logo img {
        width: 130px;
    }

    /* Hamburger button */
    .menu-toggle {
		display: flex;
		flex: 0 0 40px;
		flex-direction: column;
		justify-content: center;
		align-items: center;
		gap: 5px;
		width: 40px;
		height: 40px;
		padding: 0;
		margin: 0;
		background: transparent;
		border: none;
		cursor: pointer;
		order: 3;
    }

    .menu-toggle span {
        display: block;
        width: 24px;
        height: 2px;
        background: #142d49;
        border-radius: 2px;
        transition: transform 0.25s ease, opacity 0.25s ease;
    }

    /* Open -> X */
    .menu-toggle.is-active span:nth-child(1) {
        transform: translateY(7px) rotate(45deg);
    }

    .menu-toggle.is-active span:nth-child(2) {
        opacity: 0;
    }

    .menu-toggle.is-active span:nth-child(3) {
        transform: translateY(-7px) rotate(-45deg);
    }

    /* Navigation dropdown */
    .site-nav {
        display: none;
        position: absolute;
        top: 100%;
        left: 0;
        right: 0;
        z-index: 1000;
        background: #fff;
        border-top: 1px solid #e5e5e5;
        box-shadow: 0 8px 15px rgba(0, 0, 0, 0.08);
    }

    .site-nav.is-open {
        display: block;
    }

    .nav-menu {
        display: flex;
        flex-direction: column;
        align-items: stretch;
        gap: 0;
        padding: 10px 20px;
    }

    .nav-menu li {
        border-bottom: 1px solid #eee;
    }

    .nav-menu li:last-child {
        border-bottom: none;
    }

    .nav-menu a {
        display: block;
        padding: 14px 5px;
        font-size: 14px;
        white-space: normal;
    }

    /* Language switcher */
    .language-switcher {
        margin-left: auto;
        order: 2;
    }

}


/* ========================================
   Hero
======================================== */

.hero {
    position: relative;
    display: flex;
    align-items: center;
    min-height: 540px;
    overflow: hidden;
	margin: 0;
    background:
        linear-gradient(
            90deg,
            rgba(10, 35, 55, 0.75) 0%,
            rgba(10, 35, 55, 0.35) 55%,
            rgba(10, 35, 55, 0.05) 100%
        ),
        url("../images/top_01.jpg") center center / cover no-repeat;
}

.hero-inner {
    position: relative;
    z-index: 1;
    width: min(1200px, 90%);
    margin: 0 auto;
    padding: 100px 0;
}

.hero-accent {
    width: 64px;
    height: 4px;
    margin-bottom: 32px;
    background: var(--color-green);
}

.hero h1 {
    margin: 0 0 24px;
	font-family: var(--font-heading);
    color: #ffffff;
    font-size: clamp(38px, 5vw, 68px);
    font-weight: 700;
    line-height: 1.2;
    letter-spacing: -0.035em;
}

.hero-subtitle {
    margin: 0;
    font-family: var(--font-body);
    color: #ffffff;
    font-size: clamp(16px, 1.7vw, 21px);
    font-weight: 600;
    line-height: 1.4;
}

/* Hero専用のタンパク質モチーフ */
.hero .protein-strand-front {
    stroke: #b5dadd;
}

.hero .protein-strand-back {
    stroke: #b5dadd;
    opacity: 0.25;
}


/* Decorative background */

.hero::after {
	display: none;
    /*content: "";
    position: absolute;

    width: 480px;
    height: 480px;
    right: -100px;
    top: 50%;
    transform: translateY(-50%);
    border: 1px solid rgba(79, 129, 189, 0.18);
    border-radius: 50%;
    box-shadow:
        0 0 0 70px rgba(79, 129, 189, 0.035),
        0 0 0 140px rgba(0, 127, 137, 0.025);
    pointer-events: none;*/
}

/* Mobile */

@media (max-width: 768px) {

    .hero {
        min-height: 440px;
    }

    .hero-inner {
        padding: 80px 0;
    }

    .hero h1 {
        font-size: clamp(34px, 8vw, 48px);
    }

    .hero-subtitle br {
        display: none;
    }

    .hero::after {
        width: 300px;
        height: 300px;
        right: -180px;
        opacity: 0.6;
    }
}

/* ========================================
   Footer
======================================== */

.site-footer {
    background: #142d49;
    color: #fff;
    padding: 48px 0 24px;
	margin-top: 96px;
}

.footer-inner {
    width: min(1200px, calc(100% - 48px));
    margin: 0 auto;
}

/* Upper area */
.footer-top {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 40px;
    padding-bottom: 35px;
}

/* Logo */
.footer-logo {
    flex-shrink: 0;
}

.footer-logo img {
    display: block;
    width: 150px;
    height: auto;
}

/* Navigation */
.footer-nav {
    display: flex;
    flex-wrap: wrap;
    justify-content: flex-end;
    align-items: center;
    gap: 16px 24px;
}

.footer-nav a {
    color: #fff;
    font-size: 12px;
    font-weight: 600;
    line-height: 1.5;
    text-decoration: none;
    transition: color 0.2s ease;
}

.footer-nav a:hover {
    color: #39b6c0;
}

/* Copyright */
.footer-bottom {
    padding-top: 22px;
    border-top: 1px solid rgba(255, 255, 255, 0.2);
}

.footer-bottom p {
    margin: 0;
    color: #b7c5d3;
    font-size: 12px;
    line-height: 1.6;
}

.footer-menu {
    display: flex;
    flex-wrap: wrap;
    align-items: center;
    gap: 24px;
    margin: 0;
    padding: 0;
    list-style: none;
}

.footer-menu li {
    margin: 0;
    padding: 0;
}

.footer-menu a {
    text-decoration: none;
}

/* Responsive */

@media (max-width: 900px) {
    .footer-top {
        flex-direction: column;
        align-items: flex-start;
        gap: 30px;
    }

    .footer-nav {
        justify-content: flex-start;
    }
}

@media (max-width: 600px) {
    .site-footer {
		margin-top: 64px;
        padding: 35px 0 22px;
    }

    .footer-inner {
        width: calc(100% - 40px);
    }

    .footer-logo img {
        width: 130px;
    }

    .footer-nav {
        display: grid;
        grid-template-columns: 1fr 1fr;
        gap: 16px 20px;
    }

    .footer-nav a {
        font-size: 11px;
    }

    .footer-bottom p {
        font-size: 11px;
    }
}





/* ========================================
   Home - Introduction
======================================== */

.home-container {
    width: min(1100px, 90%);
    margin: 0 auto;
}

/* ========================================
   Home - Highlights
======================================== */

.home-highlights {
    padding: 32px 0 0;
}

.highlights-grid {
    display: grid;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 16px 20px;
}

.highlight-card {
    position: relative;
    display: grid;
    grid-template-columns: 48px minmax(0, 1fr);
    gap: 12px;

    padding: 20px 24px 20px 18px;
    background: #edf3f4;

    border-left: 8px solid #007f89;
    border-radius: 0 14px 14px 14px;

    box-shadow: 2px 3px 3px rgba(0, 0, 0, 0.18);
}

.highlight-number {
    color: #007f89;
    font-family: var(--font-heading);
    font-size: 26px;
    font-weight: 700;
    line-height: 1.25;
}

.highlight-content h3 {
    margin: 0 0 10px;
    color: #122c46;
    font-family: var(--font-heading);
    font-size: 24px;
    font-weight: 700;
    line-height: 1.2;
}

.highlight-content p {
    margin: 0;
    color: #122c46;
    font-family: var(--font-body);
    font-size: 16px;
    line-height: 1.45;
}

/* Tablet */
@media (max-width: 900px) {
    .highlights-grid {
        grid-template-columns: 1fr;
    }
}

/* Mobile */
@media (max-width: 600px) {
    .highlight-card {
        grid-template-columns: 36px minmax(0, 1fr);
        gap: 10px;
        padding: 18px 16px 18px 14px;
        border-radius: 0 20px 20px 20px;
    }

    .highlight-number {
        font-size: 22px;
    }

    .highlight-content h3 {
        font-size: 20px;
    }

    .highlight-content p {
        font-size: 15px;
    }
}

/* ========================================
   Home - Mission & Vision
======================================== */

.mission-item {
    margin-top: 24px;
}


/* ========================================
   Subpage - Common
======================================== */

.page-header {
    padding: 64px 0 0px;
}

.page-header h1 {
	margin: 0;    
    color: var(--color-primary);
    font-family: var(--font-heading);
    font-size: clamp(32px, 4vw, 46px);
    font-weight: 700;
    line-height: 1.2;
}

/*.page-header h1::before {
    content: "";
	margin-bottom: 24px;
    display: block;
    width: 64px;
    height: 4px;
    background: var(--color-green);
}*/

/* ========================================
   Protein Heading Decoration
======================================== */

.protein-heading .protein-decoration {
    display: block;
    width: 120px;
    height: 35px;
    max-width: none;
    margin: 8px 0 12px;
}

.protein-decoration path {
    fill: none;
    stroke-linecap: round;
    stroke-linejoin: round;
    transition: d 0.8s ease;
}

.protein-strand-back {
	/*stroke: #FADEC3;*/
    stroke: url(#protein-gradient);
    stroke-width: 1.6;
    opacity: 0.7;
}

.protein-strand-front {
    stroke: url(#protein-gradient);
	/*stroke: #65959E;*/
    stroke-width: 2.4;
}



/* Page subtitle */
.page-header .page-subtitle {
    margin: 8px 0 0;
    color: var(--color-blue);
    font-size: 24px;
    line-height: 1.2;
}

@media (max-width: 768px) {
    .page-header {
        padding: 40px 0 0;
    }
}


/* ========================================
   Industry Challenges - Diagram
======================================== */

.challenges-grid {
    display: grid;
    gap: 16px;
    margin: 32px 0;
}

.challenge-item {
    display: grid;
    grid-template-columns: 30% minmax(0, 1fr);
    gap: 24px;
    align-items: stretch;
}

.challenge-title,
.challenge-description {
    display: flex;
    align-items: center;
    padding: 20px 20px;
    border-radius: 16px;
    box-shadow: 1px 3px 3px rgba(0, 0, 0, 0.2);
}

.challenge-title {
    background: #122c46;
    color: #ffffff;
    font-family: var(--font-heading);
    font-size: 22px;
    font-weight: 700;
    line-height: 1.3;
}

.challenge-description {
    background: #edf3f4;
    color: #122c46;
    font-family: var(--font-body);
    font-size: 19px;
    line-height: 1.4;
}

/* Tablet */
@media (max-width: 900px) {
    .challenge-item {
        grid-template-columns: 35% minmax(0, 1fr);
        gap: 14px;
    }

    .challenge-title {
        font-size: 20px;
    }

    .challenge-description {
        font-size: 17px;
    }
}

/* Mobile */
@media (max-width: 600px) {
    .challenges-grid {
        gap: 20px;
        margin: 36px 0;
    }

    .challenge-item {
        grid-template-columns: 1fr;
        gap: 0;
    }

    .challenge-title {
        padding: 16px 18px;
        border-radius: 14px 14px 0 0;
        font-size: 19px;
    }

    .challenge-description {
        padding: 18px;
        border-radius: 0 0 14px 14px;
        font-size: 16px;
    }
}


/* ========================================
   Technology
======================================== */

.page-content h2:not(:first-child) {
    margin-top: 96px;
}

@media (max-width: 768px) {
    .page-content h2:not(:first-child) {
        margin-top: 48px;
    }
}

@media (max-width: 768px) {
	.page-content h2 {
        line-height: 1.3;
    }
}


/* ========================================
   Technology - Platform Diagram
======================================== */

.platform-diagram {
    display: grid;
    grid-template-columns:
        minmax(0, 1fr) 24px
        minmax(0, 1fr) 24px
        minmax(0, 1fr);
    gap: 8px;
    align-items: end;
    margin: 32px 0 0;
}

.platform-step {
    min-width: 0;
}

.platform-step h3 {
    display: flex;
    align-items: center;
    justify-content: center;
    min-height: 32px;
    margin: 0;
    color: #122c46;
    font-family: var(--font-heading);
    font-size: clamp(16px, 1.7vw, 24px);
    font-weight: 700;
    line-height: 1.2;
    text-align: center;
}

.platform-box {
    display: flex;
    align-items: center;
    gap: 16px;
    min-height: 190px;
	margin-top: 16px;
    padding: 18px 16px;
    background: #eaf4f7;
    box-shadow: 1px 3px 3px rgba(0,0,0,0.2);
}

.platform-icon {
    flex: 0 0 35%;
    max-width: 110px;
}

.platform-icon svg {
    display: block;
    width: 100%;
    height: auto;
}

.platform-text {
    min-width: 0;
}

.platform-text h4 {
    margin: 0 0 12px;
    color: #122c46;
    font-family: var(--font-heading);
    font-size: 20px;
    font-weight: 600;
    line-height: 1.3;
}

.platform-text p {
    margin: 0;
    color: #4c7390;
    font-family: var(--font-body);
    font-size: 17px;
    line-height: 1.4;
}

.platform-operator {
    display: flex;
    align-items: center;
    justify-content: center;
    height: 190px;
    color: #0095a5;
    font-size: 28px;
    font-weight: 700;
}

/* Tablet */
@media (max-width: 1050px) {
    .platform-diagram {
        grid-template-columns: 1fr;
        gap: 12px;
    }

    .platform-step h3 {
        min-height: auto;
        margin-bottom: 10px;
        font-size: 22px;
    }

    .platform-box {
        min-height: 140px;
        padding: 20px;
    }

    .platform-icon {
        flex-basis: 100px;
    }

    .platform-operator {
        height: 35px;
        font-size: 30px;
    }

    .platform-operator:last-of-type {
        /* Arrow direction is handled below */
    }

    .platform-operator:nth-of-type(4) {
        transform: rotate(90deg);
    }
}

/* Mobile */
@media (max-width: 600px) {
    .platform-diagram {
        margin: 35px 0 55px;
    }

    .platform-step h3 {
        font-size: 19px;
    }

    .platform-box {
        gap: 16px;
        min-height: 125px;
        padding: 15px;
    }

    .platform-icon {
        flex-basis: 75px;
    }

    .platform-text h4 {
        font-size: 16px;
    }

    .platform-text p {
        font-size: 15px;
    }
}



/* ========================================
   Technology - Germ Layers Diagram
======================================== */

.germ-layers {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 24px;
    margin: 32px 0 0;
}

.germ-card {
    position: relative;
    min-width: 0;
    padding: 24px;
    background: #f0f6f8;
    border-radius: 0 0 24px 24px;
    box-shadow: 0 3px 3px rgba(0, 0, 0, 0.22);
}

/* Top colored line */
.germ-card::before {
    content: "";
    position: absolute;
    top: 0;
    left: 0;
    right: 0;
    height: 16px;
    background: var(--germ-color);
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.18);
}

/* Card colors */
.germ-ectoderm {
    --germ-color: #0070c0;
}

.germ-mesoderm {
    --germ-color: #ed7000;
}

.germ-endoderm {
    --germ-color: #cccc00;
}

/* Heading */
.germ-card h3 {
    display: flex;
    align-items: center;
    gap: 14px;
    margin: 16px 0 0;
    color: #007f89;
    font-family: var(--font-heading);
    font-size: 26px;
    font-weight: 700;
    line-height: 1.2;
}

.germ-card h3::before {
    content: "";
    flex: 0 0 21px;
    width: 21px;
    height: 21px;
    background: var(--germ-color);
    border: 1px solid #007f89;
    border-radius: 50%;
}

/* Card content */
.germ-card-content {
    padding-left: 8px;
}

.germ-card h4 {
    margin: 24px 0 0;
    color: #122c46;
    font-family: var(--font-heading);
    font-size: 20px;
    font-weight: 700;
    line-height: 1.3;
}

.germ-card p {
    margin: 16px 0 0;
    color: #122c46;
    font-family: var(--font-body);
    font-size: 19px;
    line-height: 1.3;
}

.germ-card .germ-example {
    margin: 16px 0 0;
    color: #193e66;
    font-weight: 700;
	line-height: 1.3;
}

/* Tablet */
@media (max-width: 1000px) {
    .germ-layers {
        grid-template-columns: 1fr;
        gap: 25px;
    }

    .germ-card {
        padding: 25px 28px 30px;
    }
}

/* Mobile */
@media (max-width: 600px) {
    .germ-layers {
        margin: 35px 0 55px;
    }

    .germ-card {
        padding: 25px 20px 28px;
        border-radius: 24px;
    }

    .germ-card h3 {
        font-size: 22px;
        margin-bottom: 25px;
    }

    .germ-card h4 {
        font-size: 18px;
        margin-bottom: 20px;
    }

    .germ-card p {
        font-size: 16px;
        margin-bottom: 22px;
    }

    .germ-card .germ-example {
        margin-bottom: 0;
    }
}



/* ========================================
   Technology - Capability Comparison
======================================== */

.capability-table-wrap {
    width: 100%;
    margin: 32px 0 0;
    overflow-x: auto;
    -webkit-overflow-scrolling: touch;
}

.capability-table {
    width: 100%;
    min-width: 900px;
    border-collapse: collapse;
    font-family: var(--font-body);
    color: #182c43;
}

/* Header */
.capability-table thead th {
    padding: 12px 16px;
    background: #182c43;
    color: #ffffff;
    font-size: 19px;
    font-weight: 700;
    line-height: 1.2;
    text-align: center;
	vertical-align: middle;
    border: 1px solid #d6e0e4;
}

.capability-table thead th:first-child {
    width: 38%;
    text-align: left;
}

.capability-table thead th.nsis-column {
    background: #c65911;
}

/* Body */
.capability-table tbody th,
.capability-table tbody td {
    padding: 12px 16px;
    border: 1px solid #d6e0e4;
    font-size: 18px;
    line-height: 1.3;
}

.capability-table tbody th {
    font-weight: 700;
    text-align: left;
}

.capability-table tbody td {
    text-align: center;
    font-size: 22px;
}

/* Alternating row colors */
.capability-table tbody tr:nth-child(odd) {
    background: #e8f2f4;
}

.capability-table tbody tr:nth-child(even) {
    background: #ffffff;
}

/* NSiS columns */
.capability-table tbody td:nth-last-child(-n+2) {
    background: #fbe5d6;
}

/* Note */
p.note {
    margin-top: 8px;
    padding-left: 16px;
    color: #808080;
    font-size: 15px;
    line-height: 1.5;
}

/* Mobile */
@media (max-width: 768px) {
    .capability-table-wrap {
        margin-top: 35px;
    }

    .capability-table thead th {
        font-size: 16px;
    }

    .capability-table tbody th,
    .capability-table tbody td {
        font-size: 16px;
    }

    .capability-table tbody td {
        font-size: 20px;
    }

    .page-content .capability-note {
        font-size: 14px;
    }
}

.symbol-triangle {
    display: inline-block;
    font-size: 0.8em;
}



/* ========================================
   Technology - Bioprocess Comparison
======================================== */

.bioprocess-comparison {
    display: grid;
    grid-template-columns: repeat(2, minmax(0, 1fr));
    gap: 32px;
    align-items: stretch;
    margin: 32px 0 0;
}

/* Main panels */
.bioprocess-panel {
    display: flex;
    flex-direction: column;
    min-width: 0;
    padding: 22px 24px 28px;
    border-radius: 32px;
    box-shadow: 0 3px 3px rgba(0, 0, 0, 0.25);
}

.bioprocess-nsis {
    --process-color: #c92e4d;
    background: #fcf0f2;
}

.bioprocess-traditional {
    --process-color: #2872b6;
    background: #edf5fc;
}

/* Panel headings */
.bioprocess-panel h3 {
    margin: 0;
    color: var(--process-color);
    font-family: var(--font-heading);
    font-size: 30px;
    font-weight: 700;
    line-height: 1.2;
    text-align: center;
}

/* Steps */
.bioprocess-steps {
    display: flex;
    flex-direction: column;
	margin-top: 20px;
    gap: 12px;
    flex: 1;
}

.bioprocess-step {
    display: flex;
    align-items: center;
    justify-content: space-between;
    gap: 12px;
    min-height: 56px;
    padding: 12px 20px;
    background: #ffffff;
    border-radius: 11px;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.25);
    color: #182c43;
    font-family: var(--font-body);
    font-size: 19px;
    font-weight: 700;
    line-height: 1.3;
}

.bioprocess-step span {
    min-width: 0;
}

.bioprocess-step strong {
    flex-shrink: 0;
    color: var(--process-color);
    font-weight: 700;
    white-space: nowrap;
}

/* Total duration */
.bioprocess-total {
    display: flex;
    align-items: center;
    justify-content: space-around;
    gap: 15px;
    min-height: 74px;
    margin-top: 38px;
    padding: 14px 18px;
    background: var(--process-color);
    border-radius: 12px;
    box-shadow: 0 3px 4px rgba(0, 0, 0, 0.2);
    color: #ffffff;
}

.bioprocess-total strong {
    font-family: var(--font-heading);
    font-size: 28px;
    font-weight: 700;
    white-space: nowrap;
}

.bioprocess-total span {
    font-family: var(--font-body);
    font-size: 20px;
    line-height: 1.3;
}

/* Tablet */
@media (max-width: 1100px) {
    .bioprocess-comparison {
        grid-template-columns: 1fr;
        gap: 30px;
    }

    .bioprocess-panel {
        border-radius: 45px;
    }
}

/* Mobile */
@media (max-width: 600px) {
    .bioprocess-comparison {
        margin: 35px 0 55px;
        gap: 25px;
    }

    .bioprocess-panel {
        padding: 20px 16px 22px;
        border-radius: 30px;
    }

    .bioprocess-panel h3 {
        font-size: 24px;
    }

    .bioprocess-step {
        padding: 12px;
        font-size: 15px;
        min-height: 55px;
    }

    .bioprocess-total {
        flex-direction: column;
        gap: 5px;
        margin-top: 25px;
        padding: 15px;
        text-align: center;
    }

    .bioprocess-total strong {
        font-size: 26px;
    }

    .bioprocess-total span {
        font-size: 15px;
    }
}




/* ========================================
   APPLICATIONS - Product Classes
======================================== */

.applications-list {
    display: flex;
    flex-direction: column;
    gap: 16px;
    margin: 32px 0 0;
}

.application-item {
    display: grid;
    grid-template-columns: 60px minmax(0, 1fr) 195px;
    align-items: center;
    gap: 16px;
    padding: 16px 28px;
    background: #eef4f6;
    border-radius: 12px;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.22);
}

.application-item:nth-child(even) {
    background: #fff;
}

/* Number */
.application-number {
    display: flex;
    align-items: center;
    justify-content: center;
    width: 58px;
    height: 58px;
    border-radius: 6px;
    color: #fff;
    font-size: 18px;
    font-weight: 700;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.2);
}

/* Main text */
.application-info {
    min-width: 0;
}

.application-info h3 {
    margin: 0 0 8px;
    color: #142d49;
    font-family: "Aptos Display", "Aptos", sans-serif;
    font-size: 24px;
    font-weight: 700;
    line-height: 1.25;
}

.application-info p {
    margin: 0;
    color: #4b708d;
    font-size: 19px;
    line-height: 1.4;
}

/* Status */
.application-status {
    display: flex;
    flex-direction: column;
    gap: 5px;
    min-width: 0;
}

.application-count {
    color: #4b708d;
    font-size: 18px;
    font-weight: 700;
}

.application-badge {
    display: block;
    padding: 7px 12px;
    border-radius: 4px;
    color: #fff;
    font-size: 18px;
    font-weight: 700;
    line-height: 1.2;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.2);
}

/* Colors */
.application-number.teal,
.application-badge.teal {
    background: #0096a5;
}

.application-number.blue,
.application-badge.blue {
    background: #20577c;
}

.application-number.orange,
.application-badge.orange {
    background: #ed7000;
}

/* Responsive */
@media (max-width: 900px) {
    .application-item {
        grid-template-columns: 52px minmax(0, 1fr);
        gap: 12px 16px;
        padding: 18px;
    }

    .application-number {
        width: 52px;
        height: 52px;
		align-self: start;
    }

    .application-info h3 {
        font-size: 20px;
    }

    .application-info p {
        font-size: 16px;
    }

    .application-status {
        grid-column: 2;
        flex-direction: row;
        align-items: center;
        flex-wrap: wrap;
        gap: 10px;
    }

    .application-count {
        font-size: 15px;
    }

    .application-badge {
        width: auto;
        font-size: 14px;
    }
}

@media (max-width: 480px) {
    .application-item {
        grid-template-columns: 44px minmax(0, 1fr);
        gap: 12px;
        padding: 14px;
    }

    .application-number {
        width: 44px;
        height: 44px;
        font-size: 15px;
    }

    .application-info h3 {
        font-size: 18px;
    }

    .application-info p {
        font-size: 15px;
    }
}




/* ========================================
   ABOUT US
======================================== */

.about-section {
    margin-bottom: 90px;
}

.about-section:last-child {
    margin-bottom: 0;
}

@media (max-width: 768px) {
    .about-section {
        margin-bottom: 60px;
    }
}




/* ========================================
   ABOUT US - Leadership Team
======================================== */

.leadership-grid {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 24px;
    margin: 32px 0 0;
}

.leadership-card {
    min-width: 0;
    padding: 16px 24px 24px;
    background: #f0f6f8;
    border-top: 16px solid #0096a5;
    border-radius: 0 0 24px 24px;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.2);
    text-align: center;
}

/* Role and photo */
.leadership-top {
    position: relative;
    display: flex;
    justify-content: center;
    align-items: flex-start;
    min-height: 120px;
}

.leadership-role {
    position: absolute;
    top: 0;
    left: 0;
    color: #0096a5;
    font-size: 24px;
    font-weight: 700;
	line-height: 1;
}

.leadership-degree {
    display: inline-block;
    font-size: 0.85em;
    font-weight: 400;
}

.leadership-top img {
    width: 105px;
    height: 120px;
    object-fit: cover;
    object-position: center top;
}

/* Name */
.leadership-card h3 {
    margin: 16px 0 0;
    color: #182c43;
    font-family: var(--font-heading);
    font-size: 24px;
    font-weight: 700;
    line-height: 1.25;
}

/* Specialty */
.leadership-card .leadership-specialty {
    margin: 8px 0 0;
    color: #0096a5;
    font-size: 17px;
    font-weight: 500;
    line-height: 1.4;
}

/* Career */
.leadership-card .leadership-career {
    margin: 16px 0 0;
    color: #142d49;
    font-size: 17px;
    line-height: 1.4;
    text-align: left;
}

/* Tablet */
@media (max-width: 900px) {
    .leadership-grid {
        grid-template-columns: 1fr;
        max-width: 480px;
        margin-left: auto;
        margin-right: auto;
    }
}

/* Mobile */
@media (max-width: 600px) {
    .leadership-card {
        padding: 12px 20px 24px;
    }

    .leadership-card h3 {
        font-size: 20px;
    }

    .leadership-card .leadership-career {
        font-size: 14px;
    }
}




/* ========================================
   ABOUT US - Research Network
======================================== */

.network-grid {
    display: grid;
    grid-template-columns: repeat(3, minmax(0, 1fr));
    gap: 24px;
    margin: 32px 0 0;
}

.network-card {
    min-width: 0;
    padding: 16px 24px 24px;
    background: #f0f6f8;
    border-top: 14px solid #53697a;
    border-radius: 0 0 24px 24px;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.2);
}

.network-card:first-child {
    border-top-color: #0096a5;
}

.network-category {
    margin-bottom: 12px;
    color: #53697a;
    font-size: 17px;
    font-weight: 700;
    text-align: center;
}

.network-card:first-child .network-category {
    color: #0096a5;
}

.network-card h3 {
    display: flex;
    align-items: center;
    justify-content: center;
    min-height: 68px;
    margin: 0;
    color: #142d49;
    font-family: var(--font-heading);
    font-size: 24px;
    font-weight: 700;
    line-height: 1.25;
    text-align: center;
}

.network-card p {
    margin-top: 16px;
    color: #142d49;
    font-size: 17px;
    line-height: 1.35;
}

/* Tablet */
@media (max-width: 900px) {
    .network-grid {
        grid-template-columns: 1fr;
        max-width: 480px;
        margin-left: auto;
        margin-right: auto;
    }
}

/* Mobile */
@media (max-width: 600px) {
    .network-card {
        padding: 20px;
    }

    .network-card h3 {
        font-size: 22px;
        min-height: auto;
    }

    .network-card p {
        font-size: 16px;
    }
}




/* ========================================
   BUSINESS DEVELOPMENT
======================================== */




/* ========================================
   BUSINESS DEVELOPMENT - Roadmap
======================================== */

.roadmap {
    margin: 32px 0 0;
}

.roadmap-grid {
    display: grid;
    grid-template-columns: repeat(4, minmax(0, 1fr));
    gap: 16px;
    position: relative;
}

/* Dashed timeline */
.roadmap-grid::before {
    content: "";
    position: absolute;
    top: 96px;
    left: 12.5%;
    right: 12.5%;
    height: 4px;
    background: repeating-linear-gradient(
        to right,
        #0096a5 0,
        #0096a5 15px,
        transparent 15px,
        transparent 28px
    );
    z-index: 0;
}

.roadmap-item {
    display: flex;
    flex-direction: column;
    align-items: center;
    min-width: 0;
    position: relative;
}

/* Year */
.roadmap-year {
    margin-bottom: 16px;
    color: #142d49;
    font-family: var(--font-heading);
    font-size: 38px;
    font-weight: 700;
    line-height: 1.2;
}

.roadmap-final .roadmap-year {
    color: #0096a5;
}

/* Timeline circle */
.roadmap-marker {
    display: flex;
    align-items: center;
    justify-content: center;
    width: 72px;
    height: 72px;
    background: #fff;
    border: 3px solid #91a2ad;
    border-radius: 50%;
    box-shadow: 0 2px 3px rgba(0, 0, 0, 0.12);
    position: relative;
    z-index: 1;
}

.roadmap-current .roadmap-marker {
    border-color: #0096a5;
}

.roadmap-marker span {
    color: #007f89;
    font-size: 18px;
    font-weight: 700;
}

.roadmap-final .roadmap-marker {
    background: #0096a5;
    border-color: #0096a5;
}

.roadmap-final .roadmap-marker span {
    color: #fff;
    font-size: 23px;
}

/* We are here */
.roadmap-here {
    height: 36px;
    padding-top: 10px;
    color: #007f89;
    font-size: 13px;
    font-weight: 700;
    white-space: nowrap;
}

/* Cards */
.roadmap-card {
    flex: 1;
    width: 100%;
    padding: 16px 20px;
    background: #fff;
    border: 1px solid #dce5eb;
    border-radius: 8px;
    box-shadow: 0 3px 8px rgba(0, 0, 0, 0.08);
}

.roadmap-card h3 {
    display: flex;
    align-items: center;
    justify-content: center;
    min-height: 62px;
    margin: 0;
    color: #142d49;
    font-family: var(--font-heading);
    font-size: 21px;
    font-weight: 700;
    line-height: 1.25;
    text-align: center;
}

.roadmap-card p {
    margin-top: 16px;
    color: #38536a;
    font-size: 16px;
    line-height: 1.4;
}

/* 2026 */
.roadmap-current .roadmap-card {
    background: #e7f6f8;
}

/* 2029 */
.roadmap-final .roadmap-card {
    background: #0096a5;
    border-color: #0096a5;
}

.roadmap-final .roadmap-card h3,
.roadmap-final .roadmap-card p {
    color: #fff;
}

/* ========================================
   Responsive
======================================== */

@media (max-width: 768px) {

    .roadmap-grid {
        grid-template-columns: 1fr;
        gap: 30px;
        padding-left: 45px;
    }

    .roadmap-grid::before {
		display: none;
    }
	
    .roadmap-item:not(:last-child)::before {
        content: "";
        position: absolute;
        top: 17px;
        bottom: -47px;
        left: -32px;
        width: 3px;
        background: repeating-linear-gradient(
            to bottom,
            #0096a5 0,
            #0096a5 12px,
            transparent 12px,
            transparent 22px
        );
        z-index: 0;
    }	

    .roadmap-item {
        align-items: flex-start;
    }

    .roadmap-item:last-child::before {
        content: "";
        position: absolute;
        top: 17px;
        bottom: 0;
        left: -32px;
        width: 3px;
        background: #fff;
        z-index: 0;
    }	
	
    .roadmap-year {
        font-size: 28px;
        margin-bottom: 10px;
    }

    .roadmap-marker {
		position: absolute;
		top: 2px;
		left: -45px;
		width: 30px;
		height: 30px;
		border-width: 2px;
    }

    .roadmap-marker span {
        font-size: 9px;
    }

    .roadmap-final .roadmap-marker span {
        font-size: 9px;
    }

    .roadmap-here {
        height: auto;
        padding: 0;
        margin-bottom: 12px;
        font-size: 11px;
    }

    .roadmap-here:empty {
        display: none;
    }

    .roadmap-card {
        box-sizing: border-box;
    }

    .roadmap-card h3 {
        min-height: auto;
        justify-content: flex-start;
        text-align: left;
        font-size: 21px;
    }

    .roadmap-card p {
        font-size: 15px;
    }
}




/* ========================================
   COMPANY PROFILE
======================================== */

/* Table */
.company-table {
	margin-top: 24px;
    width: 100%;
    border-collapse: collapse;
    font-size: 16px;
    line-height: 1.6;
    border-left: 1px solid #dce5e9;
    border-right: 1px solid #dce5e9;	
}

.company-table th,
.company-table td {
    padding: 20px 24px;
    border-bottom: 1px solid #dce5e9;
    text-align: left;
    vertical-align: middle;
}

.company-table th {
    width: 32%;
    color: #142d49;
    background: #edf4f6;
    font-weight: 700;
}

.company-table td {
    color: #142d49;
}

.company-table tr:first-child th,
.company-table tr:first-child td {
    border-top: 1px solid #dce5e9;
}

/* Achievements */
.company-achievement {
    margin-top: 24px;
}

.company-achievement + .company-achievement {
    margin-top: 48px;
}

/* Grant total */
.company-grant-total {
    font-weight: 700;
}

.company-grant-total span {
    display: block;
    color: #38536a;
    font-size: 14px;
    font-weight: 400;
}

/* Grant table */
.company-grant-table thead th {
    background: #142d49;
    color: #fff;
}

.company-grant-table tbody td:first-child {
    width: 30%;
    font-weight: 600;
}

/* Events */
.company-event-list {
	list-style: none;
}

.company-event-list li {
	position: relative;
	padding-left: 22px;
    font-size: 17px;
    line-height: 1.7;
}

.company-event-list li::before {
    content: "→";
    position: absolute;
    left: 0;
    color: #0096a5;
    font-weight: 700;
}

.company-event-list li::marker {
    color: #0096a5;
}

/* Responsive */
@media (max-width: 768px) {

	.company-section + .company-section {
        margin-top: 60px;
    }

	 .company-table {
        font-size: 14px;
    }
	
    .company-table th,
    .company-table td {
        display: block;
        width: 100%;
        box-sizing: border-box;
        padding: 12px;
    }

    .company-table th {
		width: 35%;
        border-bottom: none;
    }

    .company-table td {
        padding-bottom: 20px;
    }

    .company-table tr:first-child td {
        border-top: none;
    }
	
    /* Company Overviewだけを対象にする */
    .company-table:not(.company-grant-table) {
        display: block;
        width: 100%;
    }

    .company-table:not(.company-grant-table) tbody,
    .company-table:not(.company-grant-table) tr {
        display: block;
        width: 100%;
    }

    .company-table:not(.company-grant-table) th,
    .company-table:not(.company-grant-table) td {
        display: block;
        box-sizing: border-box;
        width: 100%;
        padding: 12px 14px;
    }

    .company-table:not(.company-grant-table) th {
        background: #eef4f6;
        border-bottom: none;
        font-weight: 700;
    }

    .company-table:not(.company-grant-table) td {
        background: #fff;
        border-bottom: 1px solid #dce5eb;
        line-height: 1.6;
    }

	.company-achievement + .company-achievement {
		margin-top: 32px;
	}	
	
    .company-achievement h3 {
        font-size: 19px;
		line-height: 1.4;
    }

    .company-achievement p,
    .company-event-list li {
        font-size: 14px;
    }	
	
    /* Grant table */
    /*.company-grant-table {
        border-collapse: separate;
        border-spacing: 0;
    }
	
    .company-grant-table tbody tr {
        border: 1px solid #dce5eb;
    }

    .company-grant-table tbody td {
        border: none;
    }	*/

	 .company-grant-table {
        border-left: none;
        border-right: none;
    }
	
    .company-grant-table,
    .company-grant-table tbody,
    .company-grant-table tr,
    .company-grant-table td {
        display: block;
        width: 100%;
        box-sizing: border-box;
    }

    /* PC用の見出し行を非表示 */
    .company-grant-table thead {
        display: none;
    }

    /* 各助成金をカード化 */
    .company-grant-table tbody tr {
        margin-bottom: 16px;
        border: 1px solid #dce5eb;
        border-radius: 8px;
        overflow: hidden;
    }

    .company-grant-table tbody td {
        padding: 14px 16px;
        border: none;
        overflow-wrap: anywhere;
    }

    /* Grant Program */
    .company-grant-table tbody td:first-child {
        width: 100%;
        background: #eef4f6;
        color: #142d49;
        font-weight: 700;
    }

    /* Award Details */
    .company-grant-table tbody td:last-child {
        background: #fff;
        font-weight: 400;
        line-height: 1.6;
    }	
}




/* ========================================
   CONTACT
======================================== */
	
.contact-details {
    display: flex;
    flex-direction: column;
    align-items: flex-start;
    gap: 16px;
    margin-top: 24px;
}

.contact-details a {
    display: flex;
    align-items: center;
    gap: 14px;
    color: #142d49;
    font-size: 17px;
    text-decoration: none;
    transition: color 0.2s;
}

.contact-details a:hover {
    color: #0096a5;
}

.contact-details .bi {
    color: #0096a5;
    font-size: 24px;
    flex-shrink: 0;
}

@media (max-width: 768px) {
    .contact-details a {
        font-size: 14px;
        overflow-wrap: anywhere;
    }

    .contact-details .bi {
        font-size: 21px;
    }
}


/* ========================================
   Back to Top
======================================== */

.page-top {
    position: fixed;
    right: 28px;
    bottom: 28px;
    width: 48px;
    height: 48px;

    display: flex;
    align-items: center;
    justify-content: center;

    background: #00838c;
    color: #fff;
    border: none;
    border-radius: 50%;

    font-size: 22px;
    cursor: pointer;
    z-index: 1000;

    opacity: 0;
    visibility: hidden;
    transform: translateY(12px);

    transition: opacity 0.3s ease,
                visibility 0.3s ease,
                transform 0.3s ease,
                background 0.3s ease;
}

.page-top.is-visible {
    opacity: 1;
    visibility: visible;
    transform: translateY(0);
}

.page-top:hover {
    background: #006b73;
    transform: translateY(-3px);
}

@media (max-width: 768px) {
    .page-top {
        right: 16px;
        bottom: 16px;
        width: 44px;
        height: 44px;
    }
}